Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo.

@article{Shaw2008DownregulationOX,
  title={Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo.},
  author={Tanya J. Shaw and Eric Charles LaCasse and Jon P. Durkin and Barbara C Vanderhyden},
  journal={International journal of cancer},
  year={2008},
  volume={122 6},
  pages={1430-4}
}
A hallmark of cancer cells is an ability to evade apoptosis. Overexpression and/or activating mutations of prosurvival molecules such as the X-linked inhibitor of apoptosis (XIAP) contribute to this inappropriate cell survival. Our objectives were to investigate the effects of downregulation of XIAP in ovarian cancer cells in vitro and in vivo using the clinical candidate antisense oligonucleotide against XIAP, AEG35156 (AS XIAP). Three ovarian cancer cell lines were transfected with AS XIAP in… CONTINUE READING

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