Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway

Abstract

Talin1 is an adaptor protein that conjugates integrins to the cytoskeleton and regulates integrins and focal adhesion signaling. Several studies have found that Talin1 is overexpressed in several tumor types and promotes tumor progression. However, the explicit role of Talin1 in hepatocellular carcinoma (HCC) progression is still unclear and its functional… (More)
DOI: 10.1111/cas.13247

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