Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer

@article{Heller2006DownregulationOT,
  title={Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer},
  author={Gerwin Heller and Joseph Geradts and Barbara Ziegler and Irene Newsham and Martin Filipits and Eva-Maria Markis-Ritzinger and Daniela Kandioler and Walter Berger and Wolfgang Stiglbauer and Dieter Depisch and Robert Pirker and Christoph Carl Zielinski and Sabine Zoechbauer-Mueller},
  journal={Breast Cancer Research and Treatment},
  year={2006},
  volume={103},
  pages={283-291}
}
TSLC1 and DAL-1 are tumor suppressor genes involved in cell adhesion. In this study, we examined the expression and methylation pattern of these genes in breast cancer cell lines and primary breast carcinomas. TSLC1 expression was lost in 5 of 8 (63%) and DAL-1 expression was lost in 6 of 8 (75%) breast cancer cell lines, respectively. Downregulation of TSLC1 expression was observed in 43 of 50 (86%) and of DAL-1 expression in 26 of 55 (47%) primary breast carcinomas. TSLC1 methylation was… CONTINUE READING
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