Downregulation of TRAP1 sensitizes glioblastoma cells to temozolomide chemotherapy through regulating metabolic reprogramming.

@article{Wu2016DownregulationOT,
  title={Downregulation of TRAP1 sensitizes glioblastoma cells to temozolomide chemotherapy through regulating metabolic reprogramming.},
  author={Jianing Wu and Yaohua Liu and Kenka Cho and Xingli Dong and Lei Teng and Dayong Han and Huailei Liu and Xiaofeng Chen and Xin Chen and Xu Hou and Fei Peng and Yunke Bi and Chen Shen and Shiguang Zhao},
  journal={Neuroreport},
  year={2016},
  volume={27 3},
  pages={136-44}
}
Cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the 'Warburg effect.' Here, we show that the tumor necrosis factor receptor-associated protein 1 (TRAP1) is crucial for the Warburg effect in human glioblastoma multiforme (GBM). In contrast to normal brain, GBMs show increased TRAP1 expression. We used both GBM cell lines and neurospheres derived from human GBM specimens to examine the effects of Knockdown of TRAP1 on GBM cell… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…