Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

@article{Kothandapani2012DownregulationOS,
  title={Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.},
  author={Anbarasi Kothandapani and Kathirvel Gopalakrishnan and Bhaskar Kahali and David Colum Reisman and Steve M. Patrick},
  journal={Experimental cell research},
  year={2012},
  volume={318 16},
  pages={
          1973-86
        }
}
Chromatin remodeling complex SWI/SNF plays important roles in many cellular processes including transcription, proliferation, differentiation and DNA repair. In this report, we investigated the role of SWI/SNF catalytic subunits Brg1 and Brm in the cellular response to cisplatin in lung cancer and head/neck cancer cells. Stable knockdown of Brg1 and Brm enhanced cellular sensitivity to cisplatin. Repair kinetics of cisplatin DNA adducts revealed that downregulation of Brg1 and Brm impeded the… CONTINUE READING
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