Downregulation of RUNX3 and TES by hypermethylation in glioblastoma

  title={Downregulation of RUNX3 and TES by hypermethylation in glioblastoma},
  author={Wolf H. M{\"u}ller and Catherine L. Nutt and Mathias Ehrich and Markus J Riemenschneider and Andreas von Deimling and Dirk van den Boom and David N Louis},
Glioblastoma, the most aggressive and least treatable form of malignant glioma, is the most common human brain tumor. Although many regions of allelic loss occur in glioblastomas, relatively few tumor suppressor genes have been found mutated at such loci. To address the possibility that epigenetic alterations are an alternative means of glioblastoma gene inactivation, we coupled pharmacological manipulation of methylation with gene profiling to identify potential methylation-regulated, tumor… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 64 extracted citations


Publications referenced by this paper.
Showing 1-10 of 79 references

Similar Papers

Loading similar papers…