Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma.

@article{Lu2019DownregulationOR,
  title={Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma.},
  author={Yingjuan June Lu and Ying-ru Li and Zhangsong Wang and Shule Xie and Qing Wang and Xinyuan Lei and Yi Ruan and Jinsong Li},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2019},
  volume={112},
  pages={
          108608
        }
}
  • Y. Lu, Ying-ru Li, +5 authors Jinsong Li
  • Published 2019
  • Biology, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Repulsive guidance molecules comprise a group of proteins that play an important role in carcinogenesis through interactions with their receptors, but their function in oral squamous cell carcinoma (OSCC) is unclear. Here, we investigated the potential role of the RGM family members in oral cancer pathogenesis. Our study showed that only RGMA was significantly downregulated in the OSCC tissues analyzed by TCGA and validated this finding in OSCC cells. The decreased expression of RGMA was… Expand
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