Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes

@article{Liu2011DownregulationOP,
  title={Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes},
  author={Y. Liu and H. Zhu and M. Liu and Jinfeng Du and Yuyan Qian and Yongjun Wang and F. Ding and X. Gu},
  journal={FEBS Letters},
  year={2011},
  volume={585}
}
Glial fibrillary acidic protein (GFAP) is a principal intermediate filament in mature astrocytes of the central nervous system (CNS), and the regulation of GFAP transcription has not been well understood yet. In the present study, we reported paired box 3 protein (Pax3) as a novel regulator of GFAP transcription, which could bind the promoter region of GFAP and down regulate the GFAP level during the serum‐induced astrocyte differentiation of neural stem cells (NSCs). Moreover, the… Expand
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  • Jian Chen, L. Xia, +9 authors W. Shi
  • Medicine
  • Journal of Molecular Neuroscience
  • 2011
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