Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes

  title={Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes},
  author={Y. Liu and H. Zhu and M. Liu and Jinfeng Du and Yuyan Qian and Yongjun Wang and F. Ding and X. Gu},
  journal={FEBS Letters},
Glial fibrillary acidic protein (GFAP) is a principal intermediate filament in mature astrocytes of the central nervous system (CNS), and the regulation of GFAP transcription has not been well understood yet. In the present study, we reported paired box 3 protein (Pax3) as a novel regulator of GFAP transcription, which could bind the promoter region of GFAP and down regulate the GFAP level during the serum‐induced astrocyte differentiation of neural stem cells (NSCs). Moreover, the… Expand
GFAP expression is regulated by Pax3 in brain glioma stem cells.
Regulation of GFAP Expression
PAX3 inhibits β-Tubulin-III expression and neuronal differentiation of neural stem cell.
PAX3 Promotes Cell Migration and CXCR4 Gene Expression in Neural Crest Cells
PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways
Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas
Clinical Significance and Prognostic Value of PAX3 Expression in Human Glioma
  • Jian Chen, L. Xia, +9 authors W. Shi
  • Medicine
  • Journal of Molecular Neuroscience
  • 2011


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