Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease.

@article{Sim2019DownregulationOP,
  title={Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease.},
  author={Woo-Cheol Sim and Wonseok Lee and Hyungtai Sim and Kang-Yo Lee and Seung-Hwan Jung and You-Jin Choi and Hyun Young Kim and Keon Wook Kang and Ji-Yoon Lee and Young Jae Choi and Sang Kyum Kim and Dae Won Jun and Won Kim and Byung-Hoon Lee},
  journal={Metabolism: clinical and experimental},
  year={2019},
  pages={
          154000
        }
}
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12 Citations
Highly Influential Citations
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Background Citations
4
Methods Citations
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12 Citations

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Citation Type

Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation
TLDR
Observations demonstrate that Phgdh-dependent de novo Ser synthesis in liver hepatocytes contributes to the maintenance of systemic glucose tolerance, suppression of inflammatory response, and resistance to protein starvation.
Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation
TLDR
The collective results indicate that NCT-503 supplementation may contribute to overaccumulation of hepatic lipid, by causing hepatic serine deficiency, while dietary Serine deficiency may produce similar outcomes by affecting the gut-microbiota-liver axis.
The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation.
Serine hydroxymethyltransferase 2 (SHMT2) converts serine into glycine in the mitochondrial matrix, transferring a methyl group to tetrahydrofolate. SHMT2 plays an important role in the maintenance…
SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation
TLDR
It is demonstrated that NSAIDs induced SNX10- and CTSA-dependent degradation of LAMP2A, thereby leading to the suppression of CMA, thus leading to NSAID-induced steatosis and hepatotoxicity.
TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation
TLDR
Clues about how TMAO may stimulate hepatocytes to produce Exos are provided and evidence that Exos secreted by TMAo-treated hepatocytes could be widely distributed in vivo and promote vascular inflammation is offered.
Cysteine Restriction-Specific Effects of Sulfur Amino Acid Restriction on Lipid Metabolism
TLDR
It is demonstrated that the anti-adiposity effects of SAAR are due to CR, which increased serinogenesis (serine biosynthesis from non-glucose substrates) by diverting substrates from glyceroneogenesis, essential for fatty acid/triglyceride cycling.
PHGDH as a mechanism for resistance in metabolically-driven cancers
TLDR
This review will investigate the role of 3-phosphoglycerate dehydrogenase in normal biological processes, leading to therole of PHGDH in the progression of cancer, and highlight the known mechanisms of resistance to cancer therapeutics facilitated by PHG DH biology.
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
TLDR
It is indicated that coffee consumption is associated with differential DNA methylation levels at multiple CpGs, and that coffee-associated epigenetic variations may explain the mechanism of action of coffee consumption in conferring disease risk.
Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism- and inflammation-related gene expression
The Ketogenic Diet Revisited: Beyond Ketones
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