Downregulation of PCDH9 predicts prognosis for patients with glioma.

  title={Downregulation of PCDH9 predicts prognosis for patients with glioma.},
  author={Chunlin Wang and Guanzhen Yu and Jiachuan Liu and Jinbiao Wang and Yongming Zhang and Xiuzhen Zhang and Zhimin Zhou and Zhenshan Huang},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  volume={19 4},
Recent evidence has indicated that biological markers are essential in estimating the prognosis of patients with gliomas. The aim of this study was to determine the status and clinical significance of a novel tumor suppressor, PCDH9 (protocadherin 9) in glioma using tissue microarrays and immunohistochemistry. Normal brain tissue showed strong positive immunostaining for PCDH9, but this was downregulated in the primary cerebral glial tumor samples (51.7%). Loss of PCDH9 expression was… CONTINUE READING