Downregulation of PAX6 by shRNA Inhibits Proliferation and Cell Cycle Progression of Human Non-Small Cell Lung Cancer Cell Lines

@inproceedings{Zhao2014DownregulationOP,
  title={Downregulation of PAX6 by shRNA Inhibits Proliferation and Cell Cycle Progression of Human Non-Small Cell Lung Cancer Cell Lines},
  author={Xiaoting Zhao and Wen-tao Yue and Lina Zhang and Li Ma and Wenyun Jia and Zhe Qian and Chunyan Zhang and Yue Wang},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND The transcription factor PAX6 is primarily expressed in embryos. PAX6 is also expressed in several tumors and plays an oncogenic role. However, little is known about the role of PAX6 in lung cancer. METHODS The function of PAX6 in lung cancer cells was evaluated by small interfering RNA-mediated depletion of the protein followed by analyses of cell proliferation, anchorage-independent growth, and cell cycle arrest. The changes of cyclin D1, pRB, ERK1/2, p38 expression caused by… CONTINUE READING

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