• Corpus ID: 26198474

Downregulation of NEK 11 is associated with drug resistance in ovarian cancer

@inproceedings{LiuDownregulationON,
  title={Downregulation of NEK 11 is associated with drug resistance in ovarian cancer},
  author={Xia Liu and Yutao Gao and Luo Yi and Jian Zhang and Li Li and Fuqiang Yin}
}
3 Citations

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Cross-validation of genes potentially associated with overall survival and drug resistance in ovarian cancer.

Complete analyses that including RT-qPCR, bioinformatics analysis and clinical data revealed an association of CKAP2, BCHE, CLDN10 and OVGP1 with drug resistance in OC, which might be prognostic factors as well as potential therapeutic targets in the treatment of OC.

Downregulation of transient receptor potential cation channel, subfamily C, member 1 contributes to drug resistance and high histological grade in ovarian cancer.

A significant and consistent downregulation of TRPC1 in drug-resistant OC tissues/cells was determined using real-time quantitative polymerase chain reaction assays and the microarrays deposited in Oncomine and Gene Expression Omnibus profiles, providing the basis for further investigations of the drug-resistance-related functions of TR PC1 in OC and other forms of cancer.

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