Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages

@article{Hyslop2005DownregulationON,
  title={Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic Lineages},
  author={L. Hyslop and M. Stojkovic and L. Armstrong and T. Walter and P. Stojkovic and S. Przyborski and M. Herbert and A. Murdoch and T. Strachan and M. Lako},
  journal={STEM CELLS},
  year={2005},
  volume={23}
}
The homeobox transcription factor Nanog has been proposed to play a crucial role in the maintenance of the undifferentiated state of murine embryonic stem cells. A human counterpart, NANOG, has been identified, but its function and localization have not hitherto been described. We have used a combination of RNA interference and quantitative real‐time polymerase chain reaction to study NANOG in human embryonic stem and embryonic carcinoma cells. Transfection of NANOG‐specific small interfering… Expand
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  • Biochemical and biophysical research communications
  • 2007
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