Downregulation of Metabolic Gene Expression in Failing Human Heart before and after Mechanical Unloading

@article{Razeghi2002DownregulationOM,
  title={Downregulation of Metabolic Gene Expression in Failing Human Heart before and after Mechanical Unloading},
  author={Peter Razeghi and Martin E. Young and Jun Ying and Christophe Depr{\'e} and Ivan P Uray and June Kolesar and Gregory L. Shipley and Christine S. Moravec and Peter J. A. Davies and O. Howard Frazier and Heinrich Taegtmeyer},
  journal={Cardiology},
  year={2002},
  volume={97},
  pages={203 - 209}
}
Background: We have previously shown that several metabolic genes are downregulated in the failing human heart. We now tested the hypothesis that mechanical unloading might reverse this process. Methods: Clinical data and myocardial tissue were collected from 14 failing hearts paired for the time of implantation and explantation of a left ventricular assist device (LVAD) and compared to 10 non-failing hearts. Transcript levels for key regulators of energy metabolism and for atrial natriuretic… 

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Measured metabolites related to glucose metabolism are diminished in failing hearts, but recovered their values post-LVAD, which differed from the amino acid levels, which decreased in heart failure but did not recover following LVAD.

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