Downregulation of KLF4 and the Bcl-2/Bax ratio in advanced epithelial ovarian cancer.

Abstract

Kruppel-like factor 4 (KLF4) is a key transcriptional regulator of cell differentiation and proliferation and an altered expression of KLF4 has been reported in a number of human malignancies. In the present study, we investigated KLF4 expression and its role in cell proliferation in advanced epithelial ovarian cancer (EOC). We compared KLF4, Bcl-2 and Bax… (More)

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