Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines.

@article{Fazio2012DownregulationOH,
  title={Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines.},
  author={Pietro Di Fazio and Roberta Montalbano and Daniel Neureiter and Beate Alinger and Ansgar Schmidt and Anna Lena Merkel and K. R. Quint and Matthias Ocker},
  journal={Experimental cell research},
  year={2012},
  volume={318 15},
  pages={1832-43}
}
Inhibitors of protein deacetylases represent a novel therapeutic option for cancer diseases due to their effects on transcriptional regulation by interfering with histones acetylation and on several other cellular pathways. Recently, their ability to modulate several transcription factors and, interestingly, also co-factors, which actively participate in formation and modulation of transcription complexes was shown. We here investigate whether HMGA2 (High Mobility Group AT-2 hook), a nuclear… CONTINUE READING
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