Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

  title={Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis},
  author={Dario Palmieri and Daniela D'Angelo and Teresa Valentino and Ivana de Martino and Angelo Ferraro and Anne Wierinckx and Monica Fedele and Jacqueline Trouillas and Alfredo Fusco},
Previous studies have demonstrated that high mobility group A proteins have a critical role on the onset of human pituitary adenomas. Indeed, both high mobility group A (HMGA) genes are overexpressed in pituitary adenomas, and consistently transgenic mice overexpressing either the Hmga1 or the Hmga2 gene develop mixed growth hormone/prolactin (GH-PRL)-secreting pituitary adenomas. Trisomy of chromosome 12, where HMGA2 is located, and/or amplification of the HMGA2 gene locus account for the… CONTINUE READING
31 Citations
42 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas

  • EL Wang, ZR Qian, RahmanMM, K Yoshimoto, S Yamada, E Kudo
  • Histopathology
  • 2010
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…