Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

@article{Palmieri2012DownregulationOH,
  title={Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis},
  author={Dario Palmieri and Daniela D'Angelo and Teresa Valentino and Ivana de Martino and Angelo Ferraro and Anne Wierinckx and Monica Fedele and Jacqueline Trouillas and Alfredo Fusco},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={3857-3865}
}
Previous studies have demonstrated that high mobility group A proteins have a critical role on the onset of human pituitary adenomas. Indeed, both high mobility group A (HMGA) genes are overexpressed in pituitary adenomas, and consistently transgenic mice overexpressing either the Hmga1 or the Hmga2 gene develop mixed growth hormone/prolactin (GH-PRL)-secreting pituitary adenomas. Trisomy of chromosome 12, where HMGA2 is located, and/or amplification of the HMGA2 gene locus account for the… CONTINUE READING
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Increased expression of HMGA1 correlates with tumour invasiveness and proliferation in human pituitary adenomas

  • EL Wang, ZR Qian, RahmanMM, K Yoshimoto, S Yamada, E Kudo
  • Histopathology
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