Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells.

@article{Ragina2012DownregulationOH,
  title={Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells.},
  author={Neli P. Ragina and K. P. Schlosser and Jason Glenn Knott and Patricia K. Senagore and Pamela J. Swiatek and Eun Ah Chang and Walid D Fakhouri and Brian C. Schutte and Matti Kiupel and Jose Bernardo Cibelli},
  journal={Stem cells and development},
  year={2012},
  volume={21 7},
  pages={
          1134-44
        }
}
Parthenogenetic embryonic stem cells (P-ESCs) offer an alternative source of pluripotent cells, which hold great promise for autologous transplantation and regenerative medicine. P-ESCs have been successfully derived from blastocysts of several mammalian species. However, compared with biparental embryonic stem cells (B-ESCs), P-ESCs are limited in their ability to fully differentiate into all 3 germ layers. For example, it has been observed that there is a differentiation bias toward ectoderm… CONTINUE READING

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