Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells.

  title={Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells.},
  author={Neli P. Ragina and K. Schlosser and J. Knott and P. Senagore and P. Swiatek and E. A. Chang and W. Fakhouri and B. C. Schutte and M. Kiupel and J. Cibelli},
  journal={Stem cells and development},
  volume={21 7},
  • Neli P. Ragina, K. Schlosser, +7 authors J. Cibelli
  • Published 2012
  • Biology, Medicine
  • Stem cells and development
  • Parthenogenetic embryonic stem cells (P-ESCs) offer an alternative source of pluripotent cells, which hold great promise for autologous transplantation and regenerative medicine. P-ESCs have been successfully derived from blastocysts of several mammalian species. However, compared with biparental embryonic stem cells (B-ESCs), P-ESCs are limited in their ability to fully differentiate into all 3 germ layers. For example, it has been observed that there is a differentiation bias toward ectoderm… CONTINUE READING
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