Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.

Abstract

Calorie restriction (CR) alleviates insulin resistance and has a beneficial effect on numerous metabolic disorders, yet the underlying mechanism has not been fully elucidated. In the present study, we found that CR of mice (60% of the diet consumption compared with ad libitum mice) reduces the expression levels of Grb2 in skeletal muscle, an insulin target… (More)
DOI: 10.1152/ajpendo.90714.2008

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