Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus.

@article{Lee2005DownregulationOG,
  title={Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus.},
  author={Karim Lee and Kipyoung Jeon and Jong-Mook Kim and V Narry Kim and Dong Hee Choi and Seung Up Kim and Sunyoung Kim},
  journal={Glia},
  year={2005},
  volume={51 1},
  pages={
          1-12
        }
}
Human cytomegalovirus (HCMV) is a member of the beta-herpesvirus family, which has tropism for glial cells. It was recently reported that HCMV might play important roles in the pathogenesis of malignant glioma. In this study, we investigated the effects of the HCMV IE1 protein on the gene expression profile in the human glioblastoma cell line, U373MG by employing cDNA microarray technology. Using DNA chips containing approximately 1,000 human cDNAs, RNA samples from U373MG cells stably… CONTINUE READING
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