Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo.

@article{Chen2014DownregulationOF,
  title={Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo.},
  author={Hong Chen and Yang Zou and Hong Yang and Jingjing Wang and Hongze Pan},
  journal={International journal of oncology},
  year={2014},
  volume={45 6},
  pages={2355-64}
}
FoxM1 is a specific transcription factor that has an important function in aggressive human carcinomas, including cervical cancer. However, the specific function and internal molecular mechanism in cervical cancer remain unclear. In this study, RNAi-mediated FoxM1 knockdown inhibited cell growth. This process also decreased the migration and invasion activities of HeLa cells in vitro. Downregulation of FoxM1 inhibited tumor growth and angiogenesis in vivo. In addition, the expressions of uPA… CONTINUE READING

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