Downregulation of Filamin A interacting protein 1-like is associated with promoter methylation and induces an invasive phenotype in ovarian cancer.

@article{Burton2011DownregulationOF,
  title={Downregulation of Filamin A interacting protein 1-like is associated with promoter methylation and induces an invasive phenotype in ovarian cancer.},
  author={Elizabeth R Burton and Aneesa Gaffar and Soo Jin Lee and Folashade A Adeshuko and Kathleen D. Whitney and J Y Chung and Stephen M Hewitt and Gloria S Huang and Gary L. Goldberg and Steven K. Libutti and Mijung Kwon},
  journal={Molecular cancer research : MCR},
  year={2011},
  volume={9 8},
  pages={1126-38}
}
Ovarian cancer is the most lethal gynecologic malignancy with a five-year survival rate below 25% for patients with stages III and IV disease. Identifying key mediators of ovarian cancer invasion and metastasis is critical to the development of more effective therapeutic interventions. We previously identified Filamin A interacting protein 1-like (FILIP1L) as an important mediator of cell proliferation and migration. In addition, targeted expression of FILIP1L in tumors inhibited tumor growth… CONTINUE READING