Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells

@article{Pasder2006DownregulationOF,
  title={Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells},
  author={Orel Pasder and Sally Shpungin and Yaniv Salem and Andre Makovsky and S Vilchick and Shulamit Michaeli and Hana Malovani and Uri Nir},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={4194-4206}
}
Fer is a nuclear and cytoplasmic intracellular tyrosine kinase. Herein we show that Fer is required for cell-cycle progression in malignant cells. Decreasing the level of Fer using the RNA interference (RNAi) approach impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase. At the molecular level, knockdown of Fer resulted in the activation of the retinoblastoma protein (pRB), and this was reflected by profound hypo-phosphorylation of pRB on… CONTINUE READING
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