Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt

@inproceedings{Zong2015DownregulationOE,
  title={Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt},
  author={Yanfang Zong and Yaqian Huang and Siyao Chen and Mingzhu Zhu and Qinghua Chen and Shasha Feng and Yan Sun and Qingyou Zhang and Chaoshu Tang and Junbao Du and Hongfang Jin},
  booktitle={Oxidative medicine and cellular longevity},
  year={2015}
}
BACKGROUND The study aimed to investigate whether endogenous H2S pathway was involved in high-salt-stimulated mitochondria-related vascular endothelial cell (VEC) apoptosis. METHODS Cultured human umbilical vein endothelial cells (HUVECs) were used in the study. H2S content in the supernatant was detected. Western blot was used to detect expression of cystathionine gamma-lyase (CSE), cleaved-caspase-3, and mitochondrial and cytosolic cytochrome c (cytc). Fluorescent probes were used to… CONTINUE READING

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