Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells.

Abstract

Synergism between exposure to chemical carcinogens and infection with the hepatitis B virus (HBV) has been implicated in the high incidence of hepatocellular carcinoma. In this study we report that the HBV protein HBx, inhibits cellular DNA repair capacity in a p53-independent manner. Two alternative assays were used: the host cell reactivation assay, which… (More)

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@article{Groisman1999DownregulationOD, title={Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells.}, author={Iris Jaitovich Groisman and Rachel Cheriyan Koshy and Frank Henkler and John D. Groopman and Moulay A. Alaoui-Jamali}, journal={Carcinogenesis}, year={1999}, volume={20 3}, pages={479-83} }