Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles

@article{JadidiNiaragh2015DownregulationOC,
  title={Downregulation of CD73 in 4T1 breast cancer cells through siRNA-loaded chitosan-lactate nanoparticles},
  author={Farhad Jadidi-Niaragh and Fatemeh Atyabi and Ali Asghar Rastegari and Esmail Mollarazi and Melika Kiani and Alireza Razavi and Mehdi Yousefi and Nasim Kheshtchin and Hadi Hassannia and Jamshid Hadjati and Fazel Shokri},
  journal={Tumor Biology},
  year={2015},
  volume={37},
  pages={8403-8412}
}
The immunosuppressive factors in tumor microenvironment enhance tumor growth and suppress anti-tumor immune responses. Adenosine is an important immunosuppressive factor which can be secreted by both tumor and immune cells trough action of two cell surface ecto-nucleotidase molecules CD39 and CD73. Blocking the adenosine generating molecules has emerged as… CONTINUE READING