Downregulation of Aquaporin-1 in Alveolar Microvessels in Lungs Adapted to Chronic Heart Failure

Abstract

The threshold pressure for lung edema formation is increased in severe chronic heart failure (CHF) due to reduced microvascular permeability. The water channel aquaporin-1 (AQP1) is present in the pulmonary microvascular endothelium, and a number of studies suggest the importance of AQP1 as a molecular determinant of pulmonary microvascular water transport… (More)
DOI: 10.1007/s00408-010-9276-x

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