Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis

  title={Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis},
  author={Qi Han and Youcai Deng and Sha Chen and Rui Chen and Mingzhen Yang and Zhujun Zhang and Xiongshan Sun and Wei Wang and Ying He and Fangjie Wang and Xiaodong Pan and Peng Li and Wenjing Lai and Hongqin Luo and Pei Huang and Xiao Guan and Yafei Deng and Jun Jun Yan and Xianjie Xu and Yan Wen and An Chen and Chuanmin Hu and Xiaohui Li and Shuhui Li},
  booktitle={Scientific Reports},
Recent data have shown that the expression of lysosome-associated membrane protein type 2 A (LAMP2A), the key protein in the chaperone-mediated autophagy (CMA) pathway, is elevated in breast tumor tissues. However, the exact effects and mechanisms of CMA during breast cancer metastasis remain largely unknown. In this study, we found that the LAMP2A protein level was significantly elevated in human breast cancer tissues, particularly in metastatic carcinoma. The increased LAMP2A level was also… CONTINUE READING
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