Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.

@article{Yu2016DownregulationOA,
  title={Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry.},
  author={Changhui Yu and Wei Tang and Yuhao Wang and Qiang Shen and Bin Wang and Chunqing Cai and Xiaojing Meng and Fei Zou},
  journal={Cancer letters},
  year={2016},
  volume={376 2},
  pages={268-77}
}
The renin-angiotensin system (RAS) is an important component of the tumor microenvironment and plays a key role in promoting cancer cell proliferation, angiogenesis, metabolism, migration and invasion. Meanwhile, the arm of angiotensin-converting enzyme (ACE)2/angiotensin-(1-7) [Ang-(1-7)]/Mas axis in connection with RAS is associated with anti-proliferative, vasodilatory and anti-metastatic properties. Previous studies have shown that Ang-(1-7) reduces the proliferation of orthotopic human… CONTINUE READING