Downregulation of β-catenin by p53 involves changes in the rate of β-catenin phosphorylation and Axin dynamics

Abstract

β-Catenin, a structural component of cell–cell adhesions, is also a potent signaling molecule in the Wnt pathway activating target genes together with Lef/Tcf transcription factors. In colorectal and many other types of cancer, β-catenin is hyperactive owing to mutations in β-catenin, or in components regulating β-catenin degradation. Deregulated β-catenin… (More)
DOI: 10.1038/sj.onc.1207587

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