Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma.

@article{Li2011DownregulationAT,
  title={Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma.},
  author={Xiao-han Li and Keiji Kikuchi and Yang Zheng and Akira Noguchi and Hiroyuki Takahashi and Takeshi Nishida and Shinji Masuda and Xiang-Hong Yang and Yasuo Takano},
  journal={Oral oncology},
  year={2011},
  volume={47 3},
  pages={217-23}
}
ING4 (inhibitor of growth gene 4) is a new member of the ING gene family and is implicated in chromatin remodeling and repression of cell growth. In order to explore the roles of ING4 in head and neck squamous cell carcinoma (HNSCC), ING4 expression was assessed in 214 cases of HNSCC by immunohistochemistry using tissue microarray, and in three oral SCC cell lines by immunohistochemistry and Western blotting. Expression of ING4 was also compared to clinicopathological variables, TUNEL assay… CONTINUE READING
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