Downregulation and antiproliferative role of FHL3 in breast cancer.

  title={Downregulation and antiproliferative role of FHL3 in breast cancer.},
  author={Chang ying Niu and Zhifeng Yan and Long Cheng and Jianhua Zhu and Hao Zhang and Xiaojie Xu and Jing Lin and Qinong Ye},
  journal={IUBMB life},
  volume={63 9},
Four and a half LIM domain (FHL) protein 3 is a member of the FHL protein family that plays roles in the regulation of signal transduction, cell adhesion, survival, and mobility. FHL3 has been implicated in the development and progression of liver cancer. However, the biological function of FHL3 in other cancers remains unclear. Here, we show that FHL3 is downregulated in breast cancer patients. Using small interfering RNA (siRNA) knockdown and/or overexpression experiments, we demonstrated… CONTINUE READING