Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children

@article{Chao2014DownregulatedCE,
  title={Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children},
  author={Y Y Chao and Kang-Hsi Wu and S Chiou and S Chiang and Chih-Yang Huang and Hsiu-Ching Yang and C Chan and C. -T. Peng and Han-Ping Wu and K. Chow and Maw-Sheng Lee},
  journal={Annals of Hematology},
  year={2014},
  volume={94},
  pages={13-22}
}
The mechanisms of idiopathic severe aplastic anemia (SAA) in children are not completely understood. Insufficiency of the bone marrow microenvironment, in which mesenchymal stem cells (MSCs) are an important element, can be a potential factor associated with hematopoietic impairment. In the current study, we studied whether aberrant gene expression could be found in MSCs from children with SAA. Using microarray analysis, two different patterns of global gene expression were detected in the SAA… CONTINUE READING