Down syndrome mouse models are looking up.

  title={Down syndrome mouse models are looking up.},
  author={Roger H Reeves},
  journal={Trends in molecular medicine},
  volume={12 6},
A new mouse model of Down syndrome (DS) carries a copy of human chromosome 21 (Hsa21), in addition to a full complement of mouse chromosomes. In terms of the number of trisomic genes represented, this model, known as 'Tc1', is closer to the genetic background of DS than any previous model. The Tc1 model not only recapitulates several of the DS features present in other mouse models but also exhibits heart defects that are similar to those that make trisomy 21 the leading cause of congenital… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…