Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

  title={Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging},
  author={D. Patterson and D. C. Cabelof},
  journal={Mechanisms of Ageing and Development},
  • D. Patterson, D. C. Cabelof
  • Published 2012
  • Biology, Medicine
  • Mechanisms of Ageing and Development
  • Down syndrome is a condition of intellectual disability characterized by accelerated aging. As with other aging syndromes, evidence accumulated over the past several decades points to a DNA repair defect inherent in Down syndrome. This evidence has led us to suggest that Down syndrome results in reduced DNA base excision repair (BER) capacity, and that this contributes to the genomic instability and the aging phenotype of Down syndrome. We propose important roles for microRNA and/or folate… CONTINUE READING
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