Down syndrome and the enteric nervous system

@article{Moore2008DownSA,
  title={Down syndrome and the enteric nervous system},
  author={Samuel W. Moore},
  journal={Pediatric Surgery International},
  year={2008},
  volume={24},
  pages={873-883}
}
  • S. Moore
  • Published 17 July 2008
  • Medicine
  • Pediatric Surgery International
Down syndrome (DS) is the most common chromosomal abnormality occurring in humans. Up to 77% of DS children have associated gastrointestinal (GI) abnormalities, which may be structural or functional in nature. Functional disturbances may, in turn, affect the outcome of corrective surgical procedures, prompting to caution. It is becoming clear that the processes affecting the enteric nervous system (ENS) in DS not only affect the micro-anatomy but also nerve function, and there is some… 
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TLDR
The association of neurological difficulties in patients with HSCR presents many challenges and management could involve the exploration and evaluation of alternative treatment choices.
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TLDR
Research into HSCR and the development of enteric neurons is an excellent example of the cross fertilization of ideas that can occur between human molecular geneticists and researchers using animal models.
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TLDR
The most prevalent disorder was chronic intestinal constipation, and Peptic ulcer disease, celiac disease, and biliary lithiasis were less prevalent with 3% each.
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  • S. Moore
  • Biology, Medicine
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  • 2012
TLDR
The chromosomal and Mendelian associations and their underlying signalling pathways are looked at to obtain a better understanding of the pathogenetic mechanisms involved in developing aganglionosis of the distal bowel.
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  • E. Malt, R. Dahl, +7 authors E. M. Davidsen
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  • 2013
TLDR
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Treating acid reflux disease in patients with Down syndrome: pharmacological and physiological approaches
TLDR
Down syndrome (DS) is often accompanied by gastrointestinal disease, occurring mainly in early infancy and frequently requiring therapy, and the most frequent is gastroesophageal reflux disease (GERD), which may often be misdiagnosed.
Infantile hypertrophic pyloric stenosis—genetics and syndromes
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Infantile hypertrophic pyloric stenosis is a common condition in neonates that is characterized by an acquired narrowing of the pylorus, and IHPS is associated with many clinical syndromes that have known causative mutations.
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