Down syndrome and cell-free fetal DNA in archived maternal serum.
@article{Lee2002DownSA, title={Down syndrome and cell-free fetal DNA in archived maternal serum.}, author={T. Lee and E. Leshane and G. Messerlian and J. Canick and A. Farina and W. Heber and D. Bianchi}, journal={American journal of obstetrics and gynecology}, year={2002}, volume={187 5}, pages={ 1217-21 } }
OBJECTIVE
Increased levels of cell-free fetal DNA (f-DNA) in the maternal circulation are a potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine whether f-DNA could be quantified by using archived serum and amniotic fluid, (2) examine whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control series matched for gestational age and duration of sample storage, and (3) determine whether f-DNA levels are elevated in the amniotic… CONTINUE READING
Figures, Tables, and Topics from this paper
Paper Mentions
Observational Clinical Trial
This purpose of this study is to develop noninvasive methods of prenatal diagnosis. Fetal
cells can be found in maternal blood. This study is designed to isolate these fetal cells… Expand
Conditions | Chromosome Disorders |
---|
90 Citations
Evaluation of cell-free fetal DNA as a second-trimester maternal serum marker of Down syndrome pregnancy.
- Biology, Medicine
- Clinical chemistry
- 2003
- 82
- PDF
Inverse Correlation Between Maternal Weight and Second Trimester Circulating Cell-Free Fetal DNA Levels
- Medicine
- Obstetrics and gynecology
- 2004
- 43
Circulating fetal DNA: its origin and diagnostic potential-a review.
- Biology, Medicine
- Placenta
- 2004
- 204
- PDF
Cell-free fetal DNA in the cerebrospinal fluid of women during the peripartum period.
- Medicine
- American journal of obstetrics and gynecology
- 2004
- 30
Elevated levels of total (maternal and fetal) beta-globin DNA in maternal blood from first trimester pregnancies with trisomy 21.
- Biology, Medicine
- Human reproduction
- 2007
- 11
- PDF
Hypermethylated ERG as a cell-free fetal DNA biomarker for non-invasive prenatal testing of Down syndrome.
- Biology, Medicine
- Clinica chimica acta; international journal of clinical chemistry
- 2015
- 4
Effects of Maternal and Fetal Characteristics on Cell-Free Fetal DNA Fraction in Maternal Plasma
- Medicine
- Reproductive Sciences
- 2015
- 42
Analysis of Cell-free Fetal DNA in Plasma and Serum of Pregnant Women
- Medicine
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- 2005
- 11
Cell-free DNA Fragmentation Patterns in Amniotic Fluid Identify Genetic Abnormalities and Changes due to Storage
- Biology, Medicine
- Diagnostic molecular pathology : the American journal of surgical pathology, part B
- 2008
- 6
References
SHOWING 1-10 OF 12 REFERENCES
Quantitation of fetal DNA in maternal serum in normal and aneuploid pregnancies
- Biology, Medicine
- Human Genetics
- 2001
- 41
Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia.
- Biology, Medicine
- Clinical chemistry
- 1999
- 480
- PDF
Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21.
- Biology, Medicine
- Clinical chemistry
- 1999
- 301
- PDF
Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses
- Biology, Medicine
- Prenatal diagnosis
- 2000
- 179
Large amounts of cell-free fetal DNA are present in amniotic fluid.
- Biology, Medicine
- Clinical chemistry
- 2001
- 74
- PDF
Presence of fetal DNA in maternal plasma and serum
- Biology, Medicine
- The Lancet
- 1997
- 2,344
- Highly Influential
- PDF
Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis.
- Biology, Medicine
- American journal of human genetics
- 1998
- 1,521
- Highly Influential
- PDF
Rapid clearance of fetal DNA from maternal plasma.
- Biology, Medicine
- American journal of human genetics
- 1999
- 935
Increased cell-free fetal DNA in plasma of two women with invasive placenta.
- Biology, Medicine
- Clinical chemistry
- 2002
- 126
- PDF
Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma.
- Biology, Medicine
- Clinical chemistry
- 2002
- 191
- PDF