Down syndrome and cell-free fetal DNA in archived maternal serum.
@article{Lee2002DownSA, title={Down syndrome and cell-free fetal DNA in archived maternal serum.}, author={Thomas Lee and Erik S. Leshane and Geralyn M Messerlian and Jacob A. Canick and Antonio Farina and Walter W Heber and Diana W. Bianchi}, journal={American journal of obstetrics and gynecology}, year={2002}, volume={187 5}, pages={ 1217-21 } }
OBJECTIVE
Increased levels of cell-free fetal DNA (f-DNA) in the maternal circulation are a potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine whether f-DNA could be quantified by using archived serum and amniotic fluid, (2) examine whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control series matched for gestational age and duration of sample storage, and (3) determine whether f-DNA levels are elevated in the amniotic…
93 Citations
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