Down syndrome and cell-free fetal DNA in archived maternal serum.

  title={Down syndrome and cell-free fetal DNA in archived maternal serum.},
  author={T. Lee and E. Leshane and G. Messerlian and J. Canick and A. Farina and W. Heber and D. Bianchi},
  journal={American journal of obstetrics and gynecology},
  volume={187 5},
  • T. Lee, E. Leshane, +4 authors D. Bianchi
  • Published 2002
  • Medicine, Biology
  • American journal of obstetrics and gynecology
  • OBJECTIVE Increased levels of cell-free fetal DNA (f-DNA) in the maternal circulation are a potential noninvasive marker for fetal Down syndrome. Our objectives were to (1) determine whether f-DNA could be quantified by using archived serum and amniotic fluid, (2) examine whether serum f-DNA levels are elevated in Down syndrome pregnancies in a case-control series matched for gestational age and duration of sample storage, and (3) determine whether f-DNA levels are elevated in the amniotic… CONTINUE READING

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