Down syndrome and Alzheimer's disease: Common pathways, common goals.

@article{Hartley2015DownSA,
  title={Down syndrome and Alzheimer's disease: Common pathways, common goals.},
  author={Dean M. Hartley and Thomas Blumenthal and Maria Chrisina Carrillo and Gilbert DiPaolo and Lucille Esralew and Katheleen J. Gardiner and Ann-Charlotte E. Granholm and Khalid Iqbal and Michael Krams and Cynthia A Lemere and I. T. Lott and William C Mobley and Seth Ness and Ralph A. Nixon and Huntington Potter and Roger H Reeves and Marwan N. Sabbagh and Wayne P. Silverman and Benjamin Tycko and Michelle Sie Whitten and Thomas Wisniewski},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2015},
  volume={11 6},
  pages={
          700-9
        }
}
In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop Alzheimer's disease (AD) pathology starting in their 30s. With the current lifespan being 55 to 60 years, approximately 70% will develop dementia, and if their life expectancy continues to increase, the number of individuals developing AD will concomitantly increase. Pathogenic and mechanistic links between DS and Alzheimer's prompted the Alzheimer's… CONTINUE READING
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