Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms’ Tumor 1 expression in K562 cells

@article{Rungrojsakul2016DownregulatoryMO,
  title={Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms’ Tumor 1 expression in K562 cells},
  author={Methee Rungrojsakul and Trinnakorn Katekunlaphan and Aroonchai Saiai and Chadarat Ampasavate and Siriporn Okonogi and Colleen Sweeney and Songyot Anuchapreeda},
  journal={BMC Complementary and Alternative Medicine},
  year={2016},
  volume={16}
}
BackgroundWilms’ tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene expression, WT1 protein and mRNA stability, and cell proliferation in K562 cell line.MethodsM. siamensis seeds were obtained from the region of Chiang Mai (North of Thailand). Mammea E/BB was extracted from seeds of M. siamensis. WT1 protein… Expand
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