Corpus ID: 85903945

Down-regulation ofglucocorticoid receptor mRNA byglucocorticoid hormones andrecognition bythereceptor ofaspecific binding sequence within areceptor cDNAclone

@inproceedings{Gustafsson1986DownregulationOR,
  title={Down-regulation ofglucocorticoid receptor mRNA byglucocorticoid hormones andrecognition bythereceptor ofaspecific binding sequence within areceptor cDNAclone},
  author={A Gustafsson},
  year={1986}
}
  • A Gustafsson
  • Published 1986
  • Biology
  • A cDNAclone fortheratglucocorticoid receptor (GR)wasusedtostudy mechanisms ofGR mRNA regulation. Treatment ofrathepatoma culture cells with0.5 MAMdexamethasone caused asmall, initial increase intheGR mRNAlevel after 6hraswell asa50%to95%reduction ofthe GRmRNAlevel after 24hrofincubation whenstudied byRNA blot hybridization. After 72hr,theinitial GRmRNAlevel was restored. Thedown-regulation ofGRmRNAlevels appears to beindependent ofprotein synthesis, since italso wasobserved inthepresence… CONTINUE READING