Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells.

@article{Ahmad2009DownregulationOU,
  title={Down-regulation of uPA and uPAR by 3,3'-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells.},
  author={Aamir Ahmad and Dejuan Kong and Zhiwei Wang and Sanila H. Sarkar and S Preeya Banerjee and Fazlul H. Sarkar},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={108 4},
  pages={916-25}
}
3,3'-Diindolylmethane (DIM) is a known anti-tumor agent against breast and other cancers; however, its exact mechanism of action remains unclear. The urokinase plasminogen activator (uPA) and its receptor (uPAR) system are involved in the degradation of basement membrane and extracellular matrix, leading to tumor cell invasion and metastasis. Since uPA-uPAR system is highly activated in aggressive breast cancer, we hypothesized that the biological activity of B-DIM could be mediated via… CONTINUE READING

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