Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex.

@article{Sava1996DownregulationOT,
  title={Down-regulation of tumour gelatinase/inhibitor balance and preservation of tumour endothelium by an anti-metastatic ruthenium complex.},
  author={Gianni Sava and Ilaria Capozzi and Alberta Bergamo and Renato Gagliardi and Moreno Cocchietto and Laura Masiero and Maurizio Onisto and Enzo Alessio and Giovanni Mestroni and Spiridione Garbisa},
  journal={International journal of cancer},
  year={1996},
  volume={68 1},
  pages={60-6}
}
The anti-metastatic ruthenium complex Na[trans-RuCl4(DMSO)Im] was given i.p. at 22 and 44 mg/kg/day, on days 8-13 after tumour implantation, to mice carrying s.c. implants of MCa mammary carcinoma. The aim of the study was to compare the effects on lung metastasis formation with those on primary tumour cells. This investigation was based on flow cytometry analysis after propidium iodide and acridine orange staining, histology of tumour parenchyma and RT-PCR analysis for the type-IV collagenases… CONTINUE READING