Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos.

@article{Rahman2014DownregulationOT,
  title={Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos.},
  author={Mohammad M Rahman and Simona Rosu and Daphna Joseph-Strauss and Orna Cohen-Fix},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 7},
  pages={2602-7}
}
  • Mohammad M Rahman, Simona Rosu, +1 author Orna Cohen-Fix
  • Published 2014 in
    Proceedings of the National Academy of Sciences…
  • DOI:10.1073/pnas.1311635111
The cell cycle is a highly regulated process that enables the accurate transmission of chromosomes to daughter cells. Here we uncover a previously unknown link between the tricarboxylic acid (TCA) cycle and cell cycle progression in the Caenorhabditis elegans early embryo. We found that down-regulation of TCA cycle components, including citrate synthase, malate dehydrogenase, and aconitase, resulted in a one-cell stage arrest before entry into mitosis: pronuclear meeting occurred normally, but… CONTINUE READING