Down-regulation of transforming growth factor-beta receptors I and II is seen in lesional but not non-lesional psoriatic epidermis.

@article{Leivo1998DownregulationOT,
  title={Down-regulation of transforming growth factor-beta receptors I and II is seen in lesional but not non-lesional psoriatic epidermis.},
  author={Tiina Leivo and Ilmo Leivo and Arja Leena Kariniemi and Jorma Keski-Oja and Ismo Virtanen},
  journal={The British journal of dermatology},
  year={1998},
  volume={138 1},
  pages={57-62}
}
Transforming growth factor-beta s (TGF-beta s) are a family of growth factors with inhibitory effects on epithelial cell proliferation. Their effects are mediated by two interacting receptors, of which type I (T beta R-I) mediates signal transduction after interaction with type II (T beta R-II) carrying the TGF-beta ligand. We have studied the expression of T beta R-I and T beta R-II in psoriatic and normal human skin by using polyclonal rabbit antisera and immunohistochemistry… CONTINUE READING