Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation.

@article{Mantrova1998DownregulationOT,
  title={Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation.},
  author={E Y Mantrova and Tien Hsu},
  journal={Genes & development},
  year={1998},
  volume={12 8},
  pages={1166-75}
}
Dorsoventral (D/V) patterning in Drosophila oogenesis is initiated by the transmission of a TGF-alpha-like ligand, Gurken (Grk), from the oocyte to the anterodorsal follicle cells, activating the EGF receptor (Egfr) signaling pathway. The zinc-finger transcription factor CF2 is a negative regulator of the rhomboid (rho) gene that encodes an essential membrane-bound component of the dorsalizing pathway. Expression of CF2 itself is negatively regulated by the activated Egfr. In this report, we… CONTINUE READING
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Proteins that bind to Drosophila chorion cis - regulatory elements : A new C 2 H 2 zinc finger protein and a C 2 C 2 steroid receptorlike component

  • A. Spradling
  • Genes & Dev .
  • 1990

P - elementmediated transformation

  • D. B. Roberts
  • 1986

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