Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia

Abstract

BACKGROUND Placental malfunction in preeclampsia is believed to be a consequence of aberrant differentiation of trophoblast lineages and changes in utero-placental oxygenation. The transcription factor Snail, a master regulator molecule of epithelial-mesenchymal transition in embryonic development and in cancer, is shown to be involved in trophoblast… (More)
DOI: 10.1186/1477-7827-10-15

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