Down-regulation of the nuclear factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth.

@article{Chen2007DownregulationOT,
  title={Down-regulation of the nuclear factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth.},
  author={Jing Chen and Zhi-gang Ouyang and Sheng-hua Zhang and Yong-su Zhen},
  journal={Oncology reports},
  year={2007},
  volume={17 6},
  pages={
          1445-51
        }
}
  • Jing Chen, Zhi-gang Ouyang, +1 author Yong-su Zhen
  • Published in Oncology reports 2007
  • Biology, Medicine
  • Pancreatic cancer is now one of the most common causes of cancer death worldwide. K-ras mutations are present in up to 90% of pancreatic cancer cases. The expression of mutant K-ras activates the Akt/protein kinase B pathway, resulting in the activation of the nuclear factor-kappaB (NF-kappaB) transcriptional factor. Constitutive NF-kappaB activity plays a key role in pancreatic carcinoma. NF-kappaB has been shown to inhibit apoptosis in response to chemotherapeutic agents. In the present study… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 12 CITATIONS

    Emodin potentiates the antitumor effects of gemcitabine in pancreatic cancer cells via inhibition of nuclear factor-κB.

    VIEW 3 EXCERPTS
    CITES RESULTS & BACKGROUND
    HIGHLY INFLUENCED

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES

    A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity.

    VIEW 8 EXCERPTS
    HIGHLY INFLUENTIAL