Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease.

@article{Tilley2009DownregulationOT,
  title={Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease.},
  author={Ann E. Tilley and B P Harvey and Adriana Heguy and Neil R. Hackett and Rui Wang and Timothy P. O'Connor and Ronald G. Crystal},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 6},
  pages={457-66}
}
RATIONALE The airway epithelium of smokers is subject to a variety of mechanisms of injury with consequent modulation of epithelial regeneration and disordered differentiation. Several signaling pathways, including the Notch pathway, control epithelial differentiation in lung morphogenesis, but little is known about the role of these pathways in adults. OBJECTIVES We tested the hypotheses that Notch-related genes are expressed in the normal nonsmoker small airway epithelium of human adults… CONTINUE READING

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