Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility.

Abstract

STUDY QUESTION Does antisense oligonucleotide (ASO)-mediated down-regulation of serum fetuin-B cause infertility like fetuin-B gene deficiency in female mice? SUMMARY ANSWER Pharmacological fetuin-B down-regulation by ASO therapy results in reversible infertility in female mice. WHAT IS KNOWN ALREADY Female fetuin-B deficient (Fetub-/-) mice are… (More)
DOI: 10.1093/molehr/gaw068

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