Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues.

  title={Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues.},
  author={George Makram Yousef and Andreas Scorilas and Albert Chang and Laura M. Rendl and Maria Diamandis and Klaus Jung and Eleftherios P Diamandis},
  journal={The Prostate},
  volume={51 2},
BACKGROUND Kallikreins are a subgroup of serine proteases with diverse physiological functions. Many kallikrein genes are differentially expressed in various malignancies and prostate specific antigen (PSA; encoded by the KLK3 gene) is the best tumor marker for prostate cancer. Human glandular kallikrein (hK2; encoded by the KLK2 gene) is an emerging tumor marker for prostate cancer. KLK5 is a newly discovered human kallikrein gene which shares a high degree of homology and is located adjacent… CONTINUE READING


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Kallikreins as Biomarkers for Prostate Cancer

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